Academic Publications

Books (as Editor)

Synapse Development: Methods and Protocols, Second Edition (2025)

Together with Alexandros Poulopoulos, I co-edited this newly published volume in the Methods in Molecular Biology series (Springer), which brings together 16 chapters contributed by leading experts in the field.

A valuable resource for researchers seeking to advance our understanding of how synapses form, transform, and transmit.

Last Author Publications

Oevel, K., Hohensee, S., Kumar, A., Rosas-Brugada, I., Bartolini, F., Soykan, T.*, Haucke, V.* (2024) Rho GTPase Signaling and mDia Facilitate Endocytosis via Presynaptic Actin. eLife, Mar 19;12:RP92755

Liu, G., Kochlamazashvili, G., Puchkov, D., Müller, R., Schultz, C., Mackintosh, A.I., Vollweiter, D., Haucke, V.*, Soykan, T.* (2022) Endosomal phosphatidylinositol 3-phosphate levels control presynaptic vesicle cycling and neurotransmission. The EMBO Journal, 41(9) 1-19

Kuijpers, M., Azarnia Tehran, D., Haucke, V.*, & Soykan, T.* (2021) The axonal endolysosomal and autophagic systems. Journal of Neurochemistry, 158(3), 589–602


First Author Publications

Soykan, T., Haucke, V., & Kuijpers, M. (2021) Mechanism of synaptic protein turnover and its regulation by neuronal activity. Current Opinion in Neurobiology, 69, 76–83

Soykan, T., Kaempf, N., Sakaba, T., Vollweiter, D., Goerdeler, F., Puchkov, D., Kononenko, N.L., Haucke, V. (2017) Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron, 93(4), 854-866

Soykan, T., Haucke, V. (2016) Cell biology: Membrane kiss mediates hormone secretion. Nature,534(7608), 479-80

Soykan, T., Maritzen, T., Haucke, V. (2016) Modes and mechanisms of synaptic vesicle recycling. Current Opinion in Neurobiology, 39, 17-23

Soykan, T.*, Schneeberger, D.*, Tria, G., Buechner, C., Bader, N., Svergun, D., Tessmer, I., Poulopoulos, A., Papadopoulos T., Varoqueaux, F., Schindelin, H., Brose, N. (2014) A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. The EMBO Journal, 33(18), 2113-33

Poulopoulos, A.*, Soykan, T.*, Tuffy, L., Varoqueaux, F. Brose, N. (2012) Homodimerization and isoform-specific heterodimerization of neuroligins. Biochemical Journal, 446(2), 321-30


Additional Publications

de Bray A, Roberts AG, Armour S, Tong J, Huhn C, Gatin-Fraudet B, Roßmann K, Shilleh AH, Jiang W, Figueredo Burgos NS, Trott JPP, Viloria K, Nasteska D, Pearce A, Miyazaki S, Tomlinson JW, Owen DM, Nieves DJ, Ast J, Cyranka M, Epanchintsev A, Ämmälä C, Reimann F, Soykan T, Ladds G, Adriaenssens AE, Trapp S, Jones B, Broichhagen J, Hodson DJ. (2025) Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain. Nat Metab. 7(8):1536-1549

Mandl S, Maiwald B, Adlmanninger E, Birke R, Schlee S, Pruška A, Bittner P, Zenobi R, Soykan T, Beliu G, Broichhagen J, Hupfeld A. (2025) SNAPpa: A Photoactivatable SNAP-tag for the Spatiotemporal Control of Protein Labeling. JACS Au. 5(7):3589-3602

Kowald M, Bachollet SPJT, Benseler F, Steinecker M, Boll M, Kaushik S, Soykan T 23;5(6):2475-2490

Altas, B., Tuffy, L.P., Patrizi, A., Dimova, K., Soykan, T., Brandenburg, C., Romanowski, A.J., Whitten, J.R., Robertson, C.D., Khim, S.N., Crutcher, G.W., Ambrozkiewicz, M.C., Yagensky, O., Krueger-Burg, D., Hammer, M., Hsiao, H.-H., Laskowski, P.R., Dyck, L., Puche, A.C., Sassoè-Pognetto, M., Chua, J.J.E., Urlaub, H., Jahn, O., Brose, N., Poulopoulos, A. (2023) Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses. Biological Psychiatry, in press. 

Bolz, S., Kaempf, N., Puchkov, D., Krauss, M., Russo, G., Soykan, T., Schmied, C., Lehmann, M., Müller, R., Schultz, C., Perrais, D., Maritzen, T., Haucke, V. (2023) Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis. Neuron, 111(23), 3765-3774

Schmied, C., Soykan, T., Bolz, S., Haucke, V., Lehmann, M. (2021) SynActJ: Easy-to-use automated analysis of synaptic activity. Frontiers in Computer Science, 3:1-11

Ludolphs, M., Schneeberger, D., Soykan, T., Schäfer, J., Papadopoulos, T., Brose, N., Schindelin, H., Steinem, C. (2015) Specificity of collybistin-phosphoinositide interactions: Impact of the individual protein domains. Journal of Biological Chemistry, 291(1), 244-54

Mayer, S., Kumar, R., Jaiswal, M., Soykan, T., Ahmadian, M.R., Brose N., Betz H., Rhee JS., Papadopoulos T. (2013) Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission. Proc. Natl. Acad. Sci. USA 110, 20795-20800

Papadopoulos, T., Soykan, T. (2011) The role of Collybistin in Gephyrin clustering at inhibitory synapses: facts and open questions. Front. Cell. Neurosci. 5, 11

Hoon, M., Soykan, T.*, Falkenburger, B.*, Hammer, M., Patrizi, A., Schmidt, K.-F., Sassoè-Pognetto, M., Löwel, S., Moser, T., Taschenberger, H., Brose, N. & Varoqueaux, F. (2011) Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina. Proc. Natl. Acad. Sci. USA. 108, 3053-8

Poulopoulos, A., Aramuni, G., Meyer, G., Soykan, T., Hoon, M., Papadopoulos, T., Zhang, M., Paarmann, I., Fuchs, C., Harvey, K., Jedlicka, P., Schwarzacher, S.W., Betz, H., Harvey, R.J., Brose, N., Zhang, W. & Varoqueaux, F. (2009) Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through Gephyrin and Collybistin. Neuron 63, 628-642

(*equal contribution)